ES329462A1 - Un procedimiento para la preparacion de bencenosulfonilureas - Google Patents
Un procedimiento para la preparacion de bencenosulfonilureasInfo
- Publication number
- ES329462A1 ES329462A1 ES0329462A ES329462A ES329462A1 ES 329462 A1 ES329462 A1 ES 329462A1 ES 0329462 A ES0329462 A ES 0329462A ES 329462 A ES329462 A ES 329462A ES 329462 A1 ES329462 A1 ES 329462A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- formula
- salts
- ethers
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 methylcyclohexyl Chemical group 0.000 abstract 9
- 150000003839 salts Chemical class 0.000 abstract 4
- 235000013877 carbamide Nutrition 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 150000003672 ureas Chemical class 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000008331 benzenesulfonamides Chemical class 0.000 abstract 1
- ALZKZGUTVJXYEF-UHFFFAOYSA-N benzenesulfonylcarbamic acid Chemical class OC(=O)NS(=O)(=O)C1=CC=CC=C1 ALZKZGUTVJXYEF-UHFFFAOYSA-N 0.000 abstract 1
- JOMVGRRCEIJQFK-UHFFFAOYSA-N benzenesulfonylcarbamothioic s-acid Chemical class OC(=S)NS(=O)(=O)C1=CC=CC=C1 JOMVGRRCEIJQFK-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001714 carbamic acid halides Chemical class 0.000 abstract 1
- 125000005521 carbonamide group Chemical group 0.000 abstract 1
- 229940112021 centrally acting muscle relaxants carbamic acid ester Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- UJYAZVSPFMJCLW-UHFFFAOYSA-N n-(oxomethylidene)benzenesulfonamide Chemical class O=C=NS(=O)(=O)C1=CC=CC=C1 UJYAZVSPFMJCLW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- KWGFMMAPDMTJHX-UHFFFAOYSA-N sulfonylthiourea Chemical compound SC(=N)N=S(=O)=O KWGFMMAPDMTJHX-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 150000003560 thiocarbamic acids Chemical class 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF46721A DE1301812B (de) | 1965-07-27 | 1965-07-27 | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES329462A1 true ES329462A1 (es) | 1967-12-01 |
Family
ID=7101195
Family Applications (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0329462A Expired ES329462A1 (es) | 1965-07-27 | 1966-07-23 | Un procedimiento para la preparacion de bencenosulfonilureas |
| ES344044A Expired ES344044A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de bencenosulfonilureas. |
| ES344045A Expired ES344045A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4 - (beta-<2-metoxi- 5 -cloro-benzamido>-etil)-bencenosulfonil)-n'-ciclohexil - urea. |
| ES344047A Expired ES344047A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta- <2-metoxi- 5-bromobenzamido>-etil) - bencenosulfonil) -n'-(4-metilciclo-hexil)-urea. |
| ES344048A Expired ES344048A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta-2-metoxi-5- metil-benzamido - etil)-benzolsulfonil) - n' - (4 metil-ci- clohexil)-urea. |
| ES344049A Expired ES344049A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta-2-metoxi-4- cloro-benzamido>-etil)-bencenosulfonil)-n'-(4-metil-ciclohe-xil)-urea. |
| ES344046A Expired ES344046A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4- (beta-<2-metoxi-5-clorobenzamido>-etil) -bencenosulfonil)-n'- (4-metil-ciclo- hexil) -urea. |
| ES355476A Expired ES355476A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355477A Expired ES355477A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355480A Expired ES355480A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355475A Expired ES355475A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355479A Expired ES355479A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- cloro-benzamido>-etil) -bencenosulfonil)-n'-ciclohexil-urea. |
| ES355478A Expired ES355478A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355474A Expired ES355474A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355481A Expired ES355481A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- cloro-benzamido>-etil)-bencenosulfonil)-n'-ciclohexil-urea. |
Family Applications After (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES344044A Expired ES344044A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de bencenosulfonilureas. |
| ES344045A Expired ES344045A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4 - (beta-<2-metoxi- 5 -cloro-benzamido>-etil)-bencenosulfonil)-n'-ciclohexil - urea. |
| ES344047A Expired ES344047A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta- <2-metoxi- 5-bromobenzamido>-etil) - bencenosulfonil) -n'-(4-metilciclo-hexil)-urea. |
| ES344048A Expired ES344048A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta-2-metoxi-5- metil-benzamido - etil)-benzolsulfonil) - n' - (4 metil-ci- clohexil)-urea. |
| ES344049A Expired ES344049A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4-(beta-2-metoxi-4- cloro-benzamido>-etil)-bencenosulfonil)-n'-(4-metil-ciclohe-xil)-urea. |
| ES344046A Expired ES344046A1 (es) | 1965-07-27 | 1967-08-11 | Procedimiento para la obtencion de n-(4- (beta-<2-metoxi-5-clorobenzamido>-etil) -bencenosulfonil)-n'- (4-metil-ciclo- hexil) -urea. |
| ES355476A Expired ES355476A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355477A Expired ES355477A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355480A Expired ES355480A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355475A Expired ES355475A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355479A Expired ES355479A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- cloro-benzamido>-etil) -bencenosulfonil)-n'-ciclohexil-urea. |
| ES355478A Expired ES355478A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355474A Expired ES355474A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- clorobenzamido>-etil)-bencenosulfonil)-n'-ciclohexilurea. |
| ES355481A Expired ES355481A1 (es) | 1965-07-27 | 1968-06-26 | Procedimiento para la obtencion de n-(4-(beta-<2-metoxi-5- cloro-benzamido>-etil)-bencenosulfonil)-n'-ciclohexil-urea. |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS526985B1 (en]) |
| AT (11) | AT278032B (en]) |
| BE (2) | BE684654A (en]) |
| BR (2) | BR6681115D0 (en]) |
| CH (1) | CH478103A (en]) |
| CY (2) | CY534A (en]) |
| DE (1) | DE1301812B (en]) |
| DK (2) | DK117419B (en]) |
| ES (15) | ES329462A1 (en]) |
| FI (1) | FI45959C (en]) |
| FR (1) | FR5943M (en]) |
| GB (2) | GB1149391A (en]) |
| IL (2) | IL26016A (en]) |
| IN (3) | IN139506B (en]) |
| IS (2) | IS756B6 (en]) |
| IT (2) | IT1043760B (en]) |
| LU (2) | LU51616A1 (en]) |
| MC (1) | MC601A1 (en]) |
| MY (2) | MY7000086A (en]) |
| NL (1) | NL6610580A (en]) |
| NO (2) | NO121834B (en]) |
| SE (1) | SE328566B (en]) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670901A1 (de) * | 1967-08-09 | 1971-03-18 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE3833439A1 (de) * | 1988-10-01 | 1991-09-12 | Hoechst Ag | Verfahren zur mikronisierung von glibenclamid |
-
1965
- 1965-07-27 DE DEF46721A patent/DE1301812B/de active Pending
-
1966
- 1966-04-25 NO NO162726A patent/NO121834B/no unknown
- 1966-06-22 IL IL26016A patent/IL26016A/xx unknown
- 1966-07-08 BR BR181115/66A patent/BR6681115D0/pt unknown
- 1966-07-13 DK DK364466AA patent/DK117419B/da unknown
- 1966-07-14 IT IT15327/66A patent/IT1043760B/it active
- 1966-07-14 FI FI661889A patent/FI45959C/fi active
- 1966-07-21 IL IL26194A patent/IL26194A/xx unknown
- 1966-07-22 IS IS1581A patent/IS756B6/is unknown
- 1966-07-22 LU LU51616D patent/LU51616A1/xx unknown
- 1966-07-22 LU LU51617D patent/LU51617A1/xx unknown
- 1966-07-23 ES ES0329462A patent/ES329462A1/es not_active Expired
- 1966-07-25 AT AT824368A patent/AT278032B/de not_active IP Right Cessation
- 1966-07-25 AT AT708266A patent/AT275541B/de active
- 1966-07-25 AT AT708166A patent/AT274830B/de active
- 1966-07-25 AT AT711068A patent/AT274840B/de active
- 1966-07-25 AT AT710868A patent/AT274838B/de active
- 1966-07-25 GB GB33416/66A patent/GB1149391A/en not_active Expired
- 1966-07-25 AT AT710968A patent/AT274839B/de active
- 1966-07-25 AT AT08244/68A patent/AT279638B/de not_active IP Right Cessation
- 1966-07-25 AT AT711168A patent/AT274841B/de active
- 1966-07-25 AT AT08242/68A patent/AT278031B/de not_active IP Right Cessation
- 1966-07-25 AT AT711268A patent/AT274842B/de active
- 1966-07-25 GB GB33285/66A patent/GB1153272A/en not_active Expired
- 1966-07-26 NO NO164067A patent/NO123569B/no unknown
- 1966-07-26 MC MC636A patent/MC601A1/xx unknown
- 1966-07-26 DK DK388766AA patent/DK123652B/da unknown
- 1966-07-26 IS IS1582A patent/IS822B6/is unknown
- 1966-07-26 SE SE10158/66A patent/SE328566B/xx unknown
- 1966-07-26 IT IT17340/66A patent/IT1043761B/it active
- 1966-07-27 NL NL6610580A patent/NL6610580A/xx unknown
- 1966-07-27 CH CH1086166A patent/CH478103A/de not_active IP Right Cessation
- 1966-07-27 BE BE684654D patent/BE684654A/xx not_active IP Right Cessation
- 1966-07-27 BR BR181609/66A patent/BR6681609D0/pt unknown
- 1966-07-27 BE BE684652D patent/BE684652A/xx not_active IP Right Cessation
- 1966-07-27 JP JP41049301A patent/JPS526985B1/ja active Pending
- 1966-08-31 AT AT08241/68A patent/AT279637B/de not_active IP Right Cessation
- 1966-10-26 FR FR81659A patent/FR5943M/fr not_active Expired
-
1967
- 1967-08-11 ES ES344044A patent/ES344044A1/es not_active Expired
- 1967-08-11 ES ES344045A patent/ES344045A1/es not_active Expired
- 1967-08-11 ES ES344047A patent/ES344047A1/es not_active Expired
- 1967-08-11 ES ES344048A patent/ES344048A1/es not_active Expired
- 1967-08-11 ES ES344049A patent/ES344049A1/es not_active Expired
- 1967-08-11 ES ES344046A patent/ES344046A1/es not_active Expired
-
1968
- 1968-06-26 ES ES355476A patent/ES355476A1/es not_active Expired
- 1968-06-26 ES ES355477A patent/ES355477A1/es not_active Expired
- 1968-06-26 ES ES355480A patent/ES355480A1/es not_active Expired
- 1968-06-26 ES ES355475A patent/ES355475A1/es not_active Expired
- 1968-06-26 ES ES355479A patent/ES355479A1/es not_active Expired
- 1968-06-26 ES ES355478A patent/ES355478A1/es not_active Expired
- 1968-06-26 ES ES355474A patent/ES355474A1/es not_active Expired
- 1968-06-26 ES ES355481A patent/ES355481A1/es not_active Expired
-
1970
- 1970-04-07 CY CY53470A patent/CY534A/xx unknown
- 1970-05-22 CY CY54070A patent/CY540A/xx unknown
- 1970-12-31 MY MY197086A patent/MY7000086A/xx unknown
- 1970-12-31 MY MY1970111A patent/MY7000111A/xx unknown
-
1974
- 1974-08-24 IN IN1917/CAL/74A patent/IN139506B/en unknown
- 1974-08-24 IN IN1914/CAL/74A patent/IN139503B/en unknown
- 1974-08-24 IN IN1912/CAL/74A patent/IN139501B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19870926 |